The main objectives of this study are to identify and critically evaluate previous research articles to investigate the impact of SGLT2 inhibitors on cardiovascular disorders, evaluate the impact of SGLT2 inhibitors on main cardiovascular disorders such as myocardial infarction, myocardial isthmic, stroke, and cardiovascular death, analyze the functioning ability of SGLT2 inhibitors for the treatment of cardiovascular disorders and providing recommendations for clinical practice, and identify areas for future research in the field of SGLT2 inhibitors [22-24]. This evidence concerns the gene SLC5A2 and stroke disorder.