ACHE and Alzheimer disease: As well as, significant reduction in both (Stepanichev et al., 2017) and AChE activity was also observed in the brains of AD patients (Campanari et al., 2016), hence, the cholinergic hypothesis has arisen (Chen et al., 2022), and number of acetylcholinesterase inhibitors (AChEIs) such as donepezil, galantamine, rivastigmine are used as therapeutic agents to increase ACh concentrations in the brain and improve memory (Vecchio et al., 2021).