PTGS2 and Alzheimer disease: Other studies confirmed that high levels of COX-2 in some hippocampal neurons are correlated with the development of AD (Ho et al., 2001), but for the later stages of AD, immunostaining of post-mortem AD brains revealed that COX-2 positive neurons decrease as the disease progresses (Biringer, 2019, López and Ballaz, 2020).