It is this aberrant aggregation and accumulation of tau as seen in neuropil threads (NTs) or neurofibrillary tangles (NFTs) that are the pathological hallmark and defining feature of diverse tauopathies such as Alzheimer’s disease (AD), chronic traumatic encephalopathy (CTE), Pick’s disease (PiD), progressive supranuclear palsy (PSP), argyrophilic grain disease, and corticobasal degeneration (CBD), among others (127). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.