Cell-type specificity in tau aggregate transmission is perhaps best illustrated in the case of tau extracts derived from postmortem AD, PSP, and CBD brains injected into non-transgenic mice, where all extracts induced neuronal tau inclusions but only PSP and CBD tau strains were capable of inducing astroglial and oligodendroglial inclusions, a pattern which recapitulates authentic human neuropathology (170). This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.