MAPT and tauopathy: In keeping with the behavior of distinct strains, when seeds derived from tauopathy patients are injected into brains of transgenic mutant or WT tau overexpressing mice or non-transgenic mice, they caused templated amplification of misfolding and cell-to-cell propagation of endogenous tau aggregates with a cell-type and spatiotemporal phenotype that recapitulated the hallmark disease lesions of the extract source (169, 171, 172).