There are three primary approaches directing NK cells for cancer treatment: 1) employing NK cell antibody-dependent cellular cytotoxicity (NK cell ADCC), which is initiated through the Fc receptor CD16a on NK cells and directed by a monoclonal antibody (mAb); 2) genetically engineering CAR-NK cells that specifically target tumor antigens using the CAR and become activated; 3) developing recombinant proteins, known as NK cell engagers (NKCE), that bring tumor and NK cells into proximity and activate the NK cells (Figure 1). This evidence concerns the gene FCGR3A and neoplasm.