The incorporation of an IL-15 moiety into an NKCE that has two scFv-segments, with one binding CD16a on NK cells and the other one binding tumor-associated antigens on tumor cells, can significantly enhance the cytotoxicity of NK cells and their pro-inflammatory cytokine production compared to NKCE without IL-15 (38, 59, 60) (Table 2 and Figure 2). Here, IL15 is linked to neoplasm.