DR1 and type 1 diabetes mellitus: To the best of our knowledge, significant associations between T1D and changes in amino acids at position DRß1-26, DRß1-33, DRß1-37, DRß1-58, DRß1-67, DRß1-73, DRß1-96, DRß1-133, DRß1-140, DRß1-142, and DRß1-180, have not been reported previously, highlighting the novelty in our findings.