CD comprises only 0.02% of our T1D cohort; it is interesting to note that 47.4% carry DQA1*05:01/DQB1*02:01 encoding a DQ2.5 protein, which represents the strongest risk haplotypes associated with the celiac disease and additionally shared by T1D (53, 54). This evidence concerns the gene HLA-DQA1 and type 1 diabetes mellitus.