Furthermore, DRB1*04:05:01~DQA1*03:03:01~DQB1*03:02:01 [OR (95% CI) = 5.4 (1.64–23.16), Pc = 0.01] is the second-most significant haplotype conferring high risk of T1D and has only been reported once in a European population study (47). The gene discussed is HLA-DQA1; the disease is type 1 diabetes mellitus.