Microglial activation has been linked to retinal degeneration in CNS disorders (25) and others like Alzheimer’s, Parkinson’s, and Huntington’s diseases (26); therefore, the number of CX3CR1-positive microglia was evaluated in vivo using cSLO over a period of six weeks following HHI-LI-PRL. The gene discussed is CX3CR1; the disease is retinal degeneration.