Multi-immunofluorescence staining analysis suggested that IL-4 and IL-13 were co-expressed with the Th2 transcription factor GATA3 in ARCP and AD samples, suggesting that IL-4 and IL-13 were derived from GATA3+ Th2 cells in ARCP, similar to AD (Figure 5). Here, ARMC1 is linked to Alzheimer disease.