In mice with hepatocellular carcinoma (HCC), an increased acetate level by fecal-bacterial transplantation or direct administration of acetate inhibited the activity of HDACs, increased acetylation of sex-determining region Y-box transcription factor 13 (Sox13) at site K30, and decreased expression of Sox13, thereby reducing IL-17A production by ILC3s and retarding tumor growth. This evidence concerns the gene IL17A and hepatocellular carcinoma.