This notion is underpinned by the finding that the overexpression of LCN2 in the esophageal squamous cell carcinoma cell line EC109 resulted in the upregulation of 167 genes and downregulation of 96 genes using a 2-fold threshold encoding genes that have further capacity to interact with thousands of other proteins (90). The gene discussed is LCN2; the disease is esophageal squamous cell carcinoma.