IRF7 interacts with Foxp3/CD8+T, affects the induction of TID, the STAT1-IRF7-MHC I complex axis accelerates the process of TID through IRF7-STAT2 cascade signals and promotes the proliferation of CD8+ T cells. IRF7 interacts with MCP-1 promotes the T2D development. Here, STAT2 is linked to type 2 diabetes mellitus.