In an arthritis model, IRF7 deficiency exacerbates the clinical severity, proinflammatory cytokines are increased, anti-inflammatory cytokine IFN-β is decreased, and IRF7 regulates the expression of IFN-β in murine macrophages but not in stromal fibroblast-like synoviocytes (150). Here, IFNB1 is linked to arthritic joint disease.