Now they disclosed that IRF7 activation and nuclear translocation is detected in AIP and human type 1 AIP, blockade of IRF7 signaling pathways decreased chronic fibroinflammatory responses via the suppression of pDC-mediated IFN-I and IL-33, the IRF7-IFN-I-IL-33 axis mediates the development of AIP. Here, IRF7 is linked to autoimmune pancreatitis type 1.