Autosomal-recessive and autosomal-dominant deficiencies of IRF7 are involved in the TLR3- and IRF7-dependent induction and amplification of IFN-I (138), and TLR7 together with IRF7 combat COVID-19 by the large amounts of IFN-I produced by pDCs (139). The gene discussed is IRF7; the disease is COVID-19.