However, ADM cells with oncogenic mutations in KRAS or aberrant epidermal growth factor receptor (EGFR) signaling progress to low-grade pancreatic intraepithelial neoplasia (LG-PanIN) which are precursor lesions for PDA, or other types of pancreatic lesions (2, 25, 27). The gene discussed is KRAS; the disease is Patent ductus arteriosus.