Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 (PD-1), its ligand PD-L1, and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) pathways have become the most potent and durable cancer immunotherapy, which has been shown to increase tumor control and extend life in many cancer types (1, 2). This evidence concerns the gene CD274 and neoplasm.