CTLA4 and cancer: Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 (PD-1), its ligand PD-L1, and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) pathways have become the most potent and durable cancer immunotherapy, which has been shown to increase tumor control and extend life in many cancer types (1, 2).