CTLA4 and neoplasm: Meanwhile, the emergence of <i>RUNX1</i> mutation, upregulations of genes expression (<i>RPS27A</i>, <i>RPS6</i>, <i>UBA52</i>, <i>RACK1</i>) on tumor cells, and increased frequencies of T and NK cells with <i>TIGIT, CTLA4</i>, and <i>LAG3</i> expression were observed after midostaurin treatment, predicting the disease progression of this patient.