The 8 representative genes encoding cytokines and chemokines (IL-1β, IL-6, IL-10, TNF-α, IFN-γ, CXCL10, CXCL11), and ISG15 (interferon-stimulated gene 15, which encodes the ubiquitin-like modifier of intracellular signaling proteins), were consistently induced in the lungs during the experimental sepsis. Here, ISG15 is linked to Sepsis.