In the current study, our data demonstrate that ΔNp63α further promotes accumulation of tumor PMN-MDSCs within the tumor tissue, which correlated with the increased levels of chemokines Cxcl1 and Cxcl5. This observation is in line with previous studies demonstrating the dependence of tumor growth on host immune cells (52, 53). This evidence concerns the gene CXCL1 and neoplasm.