In the current study, our data demonstrate that ΔNp63α further promotes accumulation of tumor PMN-MDSCs within the tumor tissue, which correlated with the increased levels of chemokines Cxcl1 and Cxcl5. This observation is in line with previous studies demonstrating the dependence of tumor growth on host immune cells (52, 53). The gene discussed is CXCL5; the disease is neoplasm.