Additionally, the mRNA levels of Treg chemokine receptors Ccr4, Ccr8, and Ccr10 as well as their ligands, Ccl1, Ccl17, and Ccl22 are significantly upregulated in the v-rasHa/ΔNp63α carcinomas compared to v-rasHa/Stuffer tumors or normal skin (Figure 4B). Here, CCR4 is linked to carcinoma.