IFN-Y induces polarization of TAMs, TNF-α, and lipopolysaccharide (LPS) into the M1 (classically activated/anti-tumor) macrophage phenotype and IL-4, IL-190, TGFβ1, and PGE2, into the M2 (alternatively activated/pro-tumor) macrophage phenotype (25–28). This evidence concerns the gene TGFB1 and neoplasm.