BCL2 and B-cell chronic lymphocytic leukemia: Stimulation of T cells using αCD3/αCD28 resulted in comparable venetoclax sensitivity, indicating that T cells are able to confer protection to CLL cells in this system, which was associated with the upregulation of the anti-apoptotic Bcl-2 family members Bcl-XL and Mcl-1 (Figure 5C and 5D).