Six patients experienced TEAEs leading to study discontinuation that were considered M8891-related: deep vein thrombosis (n = 1, grade 2, 35 mg once daily M8891); platelet count decrease (n = 2, grade 3 on 35 mg once daily M8891 and grade 3 worsening to grade 4 before resolving on 60 mg once daily M8891); confusional state (n = 1, grade 2, 60 mg once daily M8891); ALT increase (n = 1, grade 3, 60 mg once daily M8891); and superficial thrombophlebitis (n = 1, grade 1, 80 mg once daily M8891). The gene discussed is GPT; the disease is deep vein thrombosis.