HCL, human cell line; UA, urolithin A; MMP, matrix metalloproteinase; ATP, adenosine triphosphate; ROS, reactive oxygen species; SIRT1, sirtuin 1; RCT, randomized controlled trial; PO, per os; CRP, C-reactive protein; RANKL, receptor activator of nuclear factor κB ligand; mRNA, messenger ribonucleic acid; PARK2, Parkinson’s disease-associated gene 2; SQSTM1, sequestosome 1; MMP-1, matrix metalloproteinase 1; DNA, deoxyribonucleic acid; UVA, ultraviolet A; Akt, Ak strain transforming kinase; MMP-9, matrix metalloproteinase 9; CCA, cholangiocarcinoma. The gene discussed is SQSTM1; the disease is cholangiocarcinoma.