PROCR and malaria: Relative to children with non-life threatening uncomplicated malaria, iRBCs isolated from the blood of children with CM express variants of Pf erythrocyte protein-1 (PfEMP1) on the iRBC surface that bind to intercellular adhesion molecule 1 (ICAM-1) and endothelial protein C receptor (EPCR) on the brain endothelial cell (EC) luminal surface (Kessler et al., 2017; Sahu et al., 2021; Ramachandran and Sharma, 2022).