In view of pathogenesis, the cellular mechanism of gout is complex and it involves Toll-like receptor signaling initiation, NF-κB signaling activation, oxidative stress, and NLRP3 signaling pathway (Liu-Bryan et al., 2005; Bauernfeind et al., 2009; Dominic et al., 2022). The gene discussed is NLRP3; the disease is gout.