Salama et al. (2023) found that the protective effects of dapagliflozin (a drug clinically used to treat type 2 diabetes) on ethanol-induced gastric injury in rats were associated with a significant reduction in RAGE levels. Moreover, excessive expression of inflammatory factors is associated with tumor promotion, which may increase the risk of gastric cancer (Fei et al., 2004). It has been recently shown that IL-17 is associated with mucosal atrophy and gastric precancerous lesions (Li et al., 2021; Qian et al., 2022). This evidence concerns the gene IL17A and gastric cancer.