ANPEP and neoplasm: Additionally, we previously discovered that treatment with HDAC inhibitors resulted in the re-establishment of the APM expression and function and also reduces tumour growth in vivo, surprisingly indicating that the loss of the APM expression can be reversed (Setiadi et al., 2005a; Setiadi et al., 2007a; Setiadi et al., 2008a; Saranchova et al., 2016; Saranchova et al., 2018; Dada et al., 2023; Nohara et al., 2023).