EPO and heart failure: The Study of Anemia in Heart Failure Trial (STAMINA-HeFT) (Ghali et al., 2008) and Reduction of Events With Darbepoetin Alfa in Heart Failure Trial (RED-HF Trial) (Swedberg et al., 2013) did not show significant clinical outcomes of using recombinant human erythropoietin (rhEP) in Heart failure patients.