PTGS1 and rheumatoid arthritis: MMP-3 plays a key role in the pathogenesis of RA and is one of the key indicators for the treatment of RA (Lerner et al., 2018) Studies have shown that when PTGS1 is overexpressed, the migration and invasion of OA synovial cells increase, and the apoptosis rate decreases (Wang et al., 2019).