Research has shown that aryl hydrocarbon receptor (AHR), caveolin-1 (CAV1), c-reactive protein (CRP), C-X-C motif chemokine 2 (CXCL2), interferon regulatory factor-1 (IRF1), secreted phosphoprotein 1 (SPP1) and other targets are key targets in the pathogenesis of arthritis (Chen et al., 2022; Wang et al., 2022; Sakthiswary et al., 2022; Zhu et al., 2022; Li et al., 2023; Yang et al., 2023), but role of them in the treatment of arthritis by CC has not been verified and further clarification is needed. This evidence concerns the gene SPP1 and arthritic joint disease.