Research has shown that aryl hydrocarbon receptor (AHR), caveolin-1 (CAV1), c-reactive protein (CRP), C-X-C motif chemokine 2 (CXCL2), interferon regulatory factor-1 (IRF1), secreted phosphoprotein 1 (SPP1) and other targets are key targets in the pathogenesis of arthritis (Chen et al., 2022; Wang et al., 2022; Sakthiswary et al., 2022; Zhu et al., 2022; Li et al., 2023; Yang et al., 2023), but role of them in the treatment of arthritis by CC has not been verified and further clarification is needed. Here, SPP1 is linked to Arthritis.