We mapped the SMAD3-related top variant “rs17293632” of coronary heart disease genome-wide association study (GWAS) data into Cis-Cardio, and the results showed that this variant was enriched in multiple cis-regulatory elements of coronary artery smooth muscle cell, which was consistent with previous research35 (Figures S1D and S1E). The gene discussed is SMAD3; the disease is coronary artery disorder.