To further characterize the functional status of the tumor-infiltrating T cells, we evaluated IFN-γ and granzyme B (GrB) in NK cells, CD4+ and CD8+ T lymphocytes in bilateral B16-OVA-bearing mice treated with mRNAs encoding LUC, IL-12, and IL-12-(αCSF1RxαPD-L1) injected in the tumor implanted in the right flank (Figure S7A). This evidence concerns the gene CD8A and neoplasm.