These findings demonstrated that CTRP3 overexpression improves renal fibrosis in the unilateral ureteral obstruction (UUO) rats and TGF-β1 induced tubular epithelial cells by the Notch signaling pathway (Chen et al., 2019) and inhibits polymeric IgA-stimulated human mesangial cells proliferation through the NF- κB signaling to attenuate the progression of IgAN (Zhang et al., 2016). Here, C1QTNF3 is linked to renal fibrosis.