Zhao et al. (2021) found that CDC20 is highly expressed in liver cancer tissues, which may regulate the proliferation and radiosensitivity of liver cancer cells with P53 mutation through the Bcl-2/Bax pathway and is a marker of poor prognosis in HCC patients. YTHDF1 is a possible prognostic marker of HCC, which when highly expressed indicates poor prognosis (Zhao et al., 2018). The gene discussed is YTHDF1; the disease is hepatocellular carcinoma.