Of the 4 hub genes, ADM was upregulated in CAD (GSE56885), PPFIA4 and TPBG were upregulated in patients with ischemic heart disease (GSE48166), and FAM162A was downregulated in patients with myocardial infarction (GSE141512) (Table 3). This evidence concerns the gene PPFIA4 and coronary artery disorder.