Pathways that are less intuitive such as Heme_metabolism include BMP-2-inducible protein kinase (50) described as promoting adaptation of GBM cells to glucose starvation, MAP2K3 linked to poor clinicopathologic features and negatively correlated with prognosis in glioma (51) and HDGF previously implicated as a serum marker of cancer progression (52). This evidence concerns the gene HDGF and glioblastoma.