The group with the lowest survival, distinguished by UV_response_DN and a lack of association with metabolic pathways observed in the intermediate and higher survival groupsin the Hallmark genesets, all similarly noted in KEGG and theWGCNA analysis, reveals a pathway signature consistent with poor prognosis in glioma via increased proliferation, hypoxia, enrichment in glioma stem cells, and radiation resistance via Notch signaling (47), IL-6_JAK_STAT3 (48, 49). The gene discussed is STAT3; the disease is central nervous system cancer.