Apart from mediating the recruitment of antitumor T cell subsets, lncRNA could orchestrate the crosstalk between cancer cells and immune cells via the release of cancer-derived chemokines such as CC-chemokine ligand 2 (CCL2), vascular endothelial growth factor A (VEGFA), fibroblast growth factor (FGF), hepatocyte growth factor (HGF), CCL5, CCL7, and CCL22 to enhance immunosuppressive lymphocyte recruitment and infiltration such as TAMs, MDSCs, and Tregs (27, 34). This evidence concerns the gene CCL2 and cancer.