Contrary to SNHG10, accumulation of lncRNA NCAL1 fuels the cytotoxicity of NK cells that target tumor cells through increasing the H3K4me3 and H3K27ac levels in the Gab2 promoter, ultimately boosting the PI3K-AKT pathway mediated by Gab2 (87). The gene discussed is GAB2; the disease is neoplasm.