Similarly, Lnc57Rik can not only bind with the C/EBPβ isoform LAP to activate C/EBPβ but also with the WDR5 that enables the enrichment of H3K4 on the promoter regions of Arg-1, NOS2, NOX2, and COX2, eventually resulting in their transcriptional activation in tumor (96). This evidence concerns the gene PTGS2 and neoplasm.