lnc-BM (a lncRNA related to breast cancer brain metastasis) in breast cancer cells binds to JAK2 and modulates its kinase activity through the lnc-BM/JAK2/STAT3/ICAM1 pathway and promotes the release of chemokine CCL2 to attract macrophages, ultimately elevating the metastatic potential of breast cancer cells to the brain (36). The gene discussed is ICAM1; the disease is breast cancer.