lnc-BM (a lncRNA related to breast cancer brain metastasis) in breast cancer cells binds to JAK2 and modulates its kinase activity through the lnc-BM/JAK2/STAT3/ICAM1 pathway and promotes the release of chemokine CCL2 to attract macrophages, ultimately elevating the metastatic potential of breast cancer cells to the brain (36). This evidence concerns the gene ICAM1 and breast carcinoma.