It has been shown that T cells co-expressing TIM-3/PD-1 are more likely to fail, and that patients who fail to respond to anti-PD-1 therapy are often highly correlated with TIM-3 expression, while patients who are resistant to PD-1 therapy are also due to selective overexpression of TIM-3, resulting in tumor immune escape (41). Here, HAVCR2 is linked to neoplasm.