(56) demonstrated that PA can trigger Caspase-3-mediated apoptosis in rat insulinoma cells through the activation of p38 mitogen-activated protein kinase (MAPK).These findings highlight the potential of targeting Bcl-2 inactivation and the modulation of caspase-3 activity in inducing apoptosis of cancer cells. Here, CASP3 is linked to pancreatic insulinoma.