In the local BLCA cohort, most Eph receptor genes (EphA3, EphA4, EphA5, EphA6, EphA7, EphA8, EphA10, EphB3, EphB4, and EPHB6) and several EFN ligand genes (EFNA3, EFNA4, and EFNB2) expressions were significantly dysregulated (p<0.05; Figure 2A). The gene discussed is EPHA6; the disease is bladder transitional cell carcinoma.