EPHA2 and familial pancreatic carcinoma: Intrinsic EphA2 expression in pancreatic cancer cells correlated with the suppression of immune response because it retains the exclusion of T cells and causes a low infiltrating level of T cells; whereas, the knockout of EphA2 gene can reverse T cell exclusion, increase the abundance of CD4+ and CD8+ T cells, and improve the sensitivity to immunotherapy (12).