In the local BLCA cohort, most Eph receptor genes (EphA3, EphA4, EphA5, EphA6, EphA7, EphA8, EphA10, EphB3, EphB4, and EPHB6) and several EFN ligand genes (EFNA3, EFNA4, and EFNB2) expressions were significantly dysregulated (p<0.05; Figure 2A). This evidence concerns the gene EFNA4 and bladder transitional cell carcinoma.