In the local BLCA cohort, most Eph receptor genes (EphA3, EphA4, EphA5, EphA6, EphA7, EphA8, EphA10, EphB3, EphB4, and EPHB6) and several EFN ligand genes (EFNA3, EFNA4, and EFNB2) expressions were significantly dysregulated (p<0.05; Figure 2A). This evidence concerns the gene EPHA3 and bladder transitional cell carcinoma.