Epigenetics refersto epi-information that exists beyond the basicsequence of DNA, is inherited, and can be passed down from generationto generation.12 Histone acetylation isa well-known epigenetic mechanism that involves the acetylation byHATs and deacetylation of histones by HDACs, which regulates geneactivity.13 Elevated HDAC levels are frequentlylinked to disease progression and poor clinical outcomes in patients.14 Additionally, the type of tissue determineswhich HDAC is in charge of the malignant cancer cell behavior. The gene discussed is HDAC9; the disease is cancer.