The emergenceof CSCs is associated with EMT, which promotes cellpluripotency and protects them from chemotherapy by enabling CSCsto persist in the tumor microenvironment.52 Significant progress has been made in the CRC CSCs over the pastdecade, with an increase in the understanding of pluripotency markers.KLF4 is a known pluripotency marker in embryonic development; however,its role in cancer is still unclear. The gene discussed is KLF4; the disease is neoplasm.