CD44 and colorectal carcinoma: Within the EpCAMhigh/CD44+ colorectal CSC population, there were E-cadherin+ andE-cadherin– CSCs.49,50 Another studydiscovered that when E-cadherin was reduced in CRC cells, the cellsshowed a mesenchymal morphology and an elevated CSC marker expressionin the colon.51 Based on our findings,we found out that HT-29 CSCs had elevated E-cadherin expression, implyingthat E-cadherin may play a role in carcinogenesis.