While cyclin D2 expression is increased in cancer,there are certain cancer types in which its expression is decreased.84,85 Cyclin D2 was found to be overexpressed in 53% of colon malignanciesand has been associated with a higher TNM stage of tumors, indicatinga possible metastatic function for CCND2.86 Park et al. discovered that CSCs had significantly higher CCND2expression. This evidence concerns the gene CCND2 and cancer.