CDH1 and cancer: Downregulation of CDH1, a marker for epithelial cells alsoknownas epithelial-cadherin, is a defining feature of cancer metastasis.Depletion of E-cadherin helps in the epithelial-mesenchymal transition(EMT).24,25 Tight junction complexes, cell polarity,and the cytoskeleton of epithelial tumor cells are lost during EMT,resulting in more invasive capabilities and phenotypes.26