TARDBP and amyotrophic lateral sclerosis: Shared neuropathological hallmarks such as the transactivation response (TAR) DNA-binding protein 43 (TDP-43) are seen not only in TBI but also in other neurodegenerative pathologies, such as Amyotrophic lateral sclerosis (ALS), for which axonal transport defects are common (Baldwin et al., 2016).