HAS2 was significantly positively correlated with TMB in four types of tumors, namely GBMLGG, LGG, SARC, THYM; and significantly negatively correlated with TMB in nine types of tumors, namely LUAD, COAD, colon adenocarcinoma/rectum adenocarcinoma esophageal carcinoma (COADREAD), ESCA, PRAD, HNSC, LUSC, LIHC, THCA. The gene discussed is HAS2; the disease is carcinoma of esophagus.