In 2 cases of UCEC, 1 case of astrocytoma, 1 case of colon adenocarcinoma (COAD), and 1 case of HNSC, a missense or nonsense mutation was detected in the glycogenin-2-3 domain of HAS3 at amino acid position 330, where arginine (R) was replaced by Q or *. Here, HAS3 is linked to colon adenocarcinoma.