HAS3 was significantly positively correlated with MSI in three types of tumors, namely UCEC, LUSC, KICH; and significantly negatively correlated with MSI in seven types of tumors, namely GBMLGG, ESCA, STES, KIPAN, STAD, rectum adenocarcinoma (READ), DLBC. The gene discussed is HAS3; the disease is rectum adenocarcinoma.