We benchmarked this workflow using a panel of three PC cell lines (22Rv1, late-passage CWR-R1, R1-I567) and one PDX (LuCaP 86.2) that are known to harbor AR gene rearrangements (15,20,35) and two PC cell lines that lack AR gene rearrangements (LNCaP-95 and VCaP). Here, AR is linked to pachyonychia congenita.