Regarding the physiological reactivity assessment, publications had to capture at least one of the previously defined physiological parameters of interest (plasma EP, plasma NEP, BP, HR, sAA, RMSSDN, PNN50, HF, ACTH, plasma or salivary cortisol, plasma renin or plasma renin activity, ANG-II, aldosterone, any coagulation or inflammatory marker, or blood lipid parameter). The gene discussed is REN; the disease is hydrops fetalis.