As indicated by echocardiographic measurements, including EF (Figure 5A), FS (Figure 5B), LVEDD (Figure 5C), LV end diastolic volume (LVEDV) (Figure 5D), LVESD (Figure 5E), and LV end systolic volume (LVESV) (Figure 5F), cardiac function declined progressively in the Corin KO mice subjected to TAC, compared to those in the sham-operated controls. This evidence concerns the gene CORIN and persistent truncus arteriosus.