In our study, Flk-1 (P = 0.0005; Figure 4C), VEGF-A (P = 0.0131; Figure 4D) and PDGF-B (P = 0.0110; Figure 4F) mRNA expression in the ischemic muscle were significantly decreased by diabetes as compared to nondiabetic controls. This evidence concerns the gene KDR and diabetes mellitus.