APLN and diabetes mellitus: However, delivery of Pyr-apelin-13 in diabetic mice significantly enhanced the amount of arterioles, from 9.71 to 17.00 vessels/mm2 (1.8-fold, P < 0.0001; Figures 3A,C), as well as the formation of capillaries, raised from 32.55 to 62.26 (1.9-fold, P < 0.0001; Figures 3A,D), suggesting that Pyr-apelin-13 treatment can promote angiogenesis/arteriogenesis in response to ischemia despite being exposed to diabetes.