Previous research indicated that interleukin-17A (IL-17A), interleukin-22(IL-22), tumor necrosis factor-α (TNF-α), and interleukin-1α (IL-1α) were pro-inflammatory cytokines in psoriasis and linked with NF-κB signalling activation (Guilloteau et al., 2010; De Simone et al., 2015). The gene discussed is TNF; the disease is psoriasis.