To date, five patients carrying somatic mutation in codon 35 of KRAS and codon 13 of HRAS with extensive EN and rhabdomyosarcoma have been reported (Bourdeaut et al., 2010; Om et al., 2017; Chang et al., 2021; Luo et al., 2021; Davies et al., 2022). The gene discussed is KRAS; the disease is rhabdomyosarcoma.