However, a major hallmark of ERMS is the occurrence of UPD at 11p15.5, a region that contains HRAS and a cluster of imprinted genes (Kratz et al., 2007; Robbins et al., 2016), including IGF2 (Figure 3C), whose increased RNA expression is a characteristic of these tumors. Here, HRAS is linked to embryonal rhabdomyosarcoma.