HDAC1 and breast cancer: ,42 The association of DACH1 and p65 promotes the recruitment of HDAC1 to the NF-κB binding at the MMP9 promoter, reducing p65 acetylation level and transcriptional activity, and inhibiting the metastasis of breast cancer cells downregulating the expression of MMP9,40 and reducing the canonical NF-κB-driven inflammation.43