Among these TWAS significant genes, ABO (enriched in artery aorta and shared by EOC with all three COVID-19 phenotypes), CRHR1-IT1 (enriched in artery aorta and prostate), and PLEKHM1 (enriched in brain cortex) were located at pleiotropic loci identified in cross-trait meta-analysis. The gene discussed is CRHR1; the disease is COVID-19.