Researchers discovered that circ-ZNF124 regulates NSCLC development by repressing miR-498 and upregulating YES1, resulting in tumor growth and increased recruitment of the Wnt/β-catenin pathway, thus downregulating Circ-ZNF124 might suppress NSCLC development partly via miR-498/YES1 modulatory complex and inactivating the Wnt/β-catenin signaling pathway (Gao et al., 2021[25]). The gene discussed is YES1; the disease is non-small cell lung carcinoma.