MMP13 and non-small cell lung carcinoma: Because MMP-13 is frequently upregulated in NSCLC, it boosts the probability of metastasis (Yu et al., 2015[133]; Hsu et al., 2006[34]), circRNA_100876 may play a role in the NSCLC cell proliferation, progression, and metastasis by modulating MMP-13 expression via its miRNA sponge function (Yao et al., 2017[127]).