ITCH as a member of the E3 ubiquitin ligases family (Bernassola et al., 2008[6]) is associated with cancer development by modulating the expression levels of p53, p73, and p63 and also adjusting the Wnt pathway via degrading Dvl and FZD4 (Aki et al., 2015[1]; Bernassola et al., 2008[6]). This evidence concerns the gene FZD4 and cancer.