ATXN3 and Spinocerebellar ataxia type 3: Additionally, in a different study using the CRISPR/Cas9 genome editing technique of precise gene repair based on HR and paired sgRNAs, He et al. demonstrated that the use of paired sgRNAs/Cas9n and HR strategy can effectively repair the 74 CAG expansions in exon 10 of ATXN3 in SCA3-iPSCs (spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cells), leading to a specific and efficient suppression of mutant ataxin-3 protein expression (He et al., 2021[32]).