SIRT1 and diabetic kidney disease: Resveratrol (RSV), a potent, natural SIRT1-agonist, reduces oxidative stress and AGE production, inhibits endoplasmic reticulum (ER) stress, and ameliorates lipotoxicity and inflammation, thereby effectively protecting renal function from DKD without significant side effects, and is widely recommended as a dietary supplement for DKD treatment (148).