TIMP3 and diabetic kidney disease: A loss of the tissue inhibitor of metalloproteinase 3 (TIMP3) aggravates basement membrane thickening, mesangial expansion, proteinuria, and interstitial fibrosis in DKD, resulting in decreased expression of FoxO1 and autophagy-related genes, while re-expression of TIMP3 in MCs attenuates these effects (102).