TNFSF11 and Alzheimer disease: Numerous inflammatory markers were verified to be significantly altered in a comparison between AD patients and controls (48), and tumour necrosis factor-alpha (TNF-α) ranges were extensively increased in the cerebrospinal fluid (CSF) and the serum of AD patients than healthy controls and associated with disorder development (49), directly potentiating bone reformation in part through synergistic interactions with RANKL and upregulating osteoclast differentiation, thus promoting bone resorption (50).